Sai Krishna Maruvada

Krishna's Research Work

Oxygen saturation in blood correlates with the tissue oxygenation levels in an organism. For the cells that are meant to work mechanistically with comparatively larger cell body, the dissolved oxygen in cells is one of the prerequisites for optimal functioning. The minimal changes in the oxygen dissolution in these cells could interfere with the quantitative energy generation and free radicle formation that make most of the active biomolecules prone to varied undesired modifications that impairs the dynamic functions.
Podocytes, are epithelial covering on the fenestrated endothelium that line the capillaries in the glomerulus. Podocytes have larger cell body and finger like cytoplasmic extensions called foot processes. These FP interdigitate with the adjacent cells (FP) and
form a sieve that permits size-based particulate filtration. These cells derive energy from the primary filtrate (usually nutrient-rich).

The nutrient requirement for these cells is high to maintain their biochemical needs; the oxygen limitation in conditions of hypertension, diabetes, ischemia, and sleep apnea will directly affect the ATP generation and functioning of cells. HIFs ( hypoxia-inducible factors) are the mediators of hypoxic signalling in most of the cells I am interested in understanding the role of HIFs in podocytes and their biology in hypoxia conditions.